Proteinuria in IgAN & Guidelines
Why proteinuria matters in IgAN
Proteinuria, or protein in the urine, is a common but often invisible sign of IgA nephropathy (IgAN).
Define:
IgA=immunoglobulin A.
People with higher levels of proteinuria may be at a greater risk of kidney failure
In a study of people with IgAN, more than 75% of people who had high levels of proteinuria and more than 50% of people with moderate levels developed kidney failure within 10 years.
Time From Diagnosis to Kidney Failure or Death in People With IgAN
Each line represents a group of patients with different amounts of protein in their urine.
Adapted with permission from Wolters Kluwer Health, Inc.: Pitcher D, Braddon F, Hendry B, et al. Long-term outcomes in IgA nephropathy. Clin J Am Soc Nephrol. 2023;18(6):727-738. https://doi.org/10.2215/CJN.0000000000000135
g/g=grams of protein per gram of creatinine in a spot (single) urine sample.
Monitoring kidney damage in IgAN
Your healthcare provider may monitor your proteinuria levels to help determine your risk of progression to kidney failure.
Current treatment guidelines for IgAN suggest 2 simultaneous approaches to lower proteinuria and the risk of kidney failure:
Supportive care to manage the consequences of chronic kidney disease
Treatment that targets the immune system and reduces the production of abnormal antibodies
Actor portrayal.
Ask your healthcare provider if a treatment that targets the source of IgAN may be right for you
Consider asking your healthcare provider these questions at your next appointment:
Have my proteinuria levels changed since my diagnosis?
Based on my proteinuria levels, what is my risk of eventually progressing to kidney failure?
Am I currently taking a treatment that targets the immune activity driving IgAN?
Two signals drive the immune activity responsible for kidney damage in IgAN
Discover 2 proteins activating B cells at the source of IgAN
INDICATION AND IMPORTANT SAFETY INFORMATION
What is TRUTAKNA?
TRUTAKNA (atacicept-vymj) is a prescription medicine used to reduce levels of protein in the urine (proteinuria) in adults with a kidney disease called primary immunoglobulin A nephropathy (IgAN), who are at risk of their disease getting worse.
It is not known if TRUTAKNA is safe and effective in children.
TRUTAKNA is approved based on reduction of proteinuria. Continued approval may depend on results from an ongoing study to determine whether TRUTAKNA slows decline in kidney function.
IMPORTANT SAFETY INFORMATION
Who should not take TRUTAKNA?
Do not take TRUTAKNA if you are allergic to atacicept-vymj or any of the ingredients in TRUTAKNA. Get emergency help if you develop signs and symptoms of an allergic reaction, including:
breathing problems
swelling of the face, eyes, lips, tongue, or throat
dizziness or lightheadedness
itching
hives
skin rash
Before using TRUTAKNA, tell your doctor about all your medical conditions, including if you:
have or think you have an infection or have infections that keep coming back.
have recently received or are scheduled to receive an immunization (vaccine). TRUTAKNA may affect your immune system response to vaccines and increase your risk of an infection from live vaccines.
You should be brought up to date with all vaccines before starting treatment with TRUTAKNA.
You should not receive live vaccines within 30 days before starting or during treatment with TRUTAKNA.
are pregnant or plan to become pregnant. It is not known if TRUTAKNA will harm your unborn baby. If you become pregnant during treatment with TRUTAKNA, you and your healthcare provider should call 1-833-633-8372.
are breastfeeding or plan to breastfeed. It is not known if TRUTAKNA passes into your breastmilk. Talk to your healthcare provider about the best way to feed your baby if you take TRUTAKNA.
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using TRUTAKNA with certain medicines may increase your risk of infections.
What are the possible side effects of TRUTAKNA?
TRUTAKNA can cause serious side effects, including:
Immunosuppression and increased risk of infections: TRUTAKNA weakens your immune system, which may increase your risk of infections. Your healthcare provider will check you for signs and symptoms of infections before you start and during treatment with TRUTAKNA. Tell your healthcare provider right away if you develop any signs or symptoms of infection, including:
fever
chills
feeling tired
cough
flu-like symptoms
aches and pains
warm, red, or painful skin
The most common side effects of TRUTAKNA include: upper respiratory tract infection and injection site reactions, such as redness, swelling, itching or skin irritation at the injection site. Your healthcare provider may interrupt treatment with TRUTAKNA if you have serious side effects.
These are not all the possible side effects of TRUTAKNA. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Vera Therapeutics at 1-833-MED-VERA or medinfo@veratx.com.
Please see Full Prescribing Information, including Patient Information.
